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International Journal of Computational Bioinformatics and In Silico Modeling
2015: Volume-4 Issue-3
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 4(3) 2015: 673-682

In Silico protein-protein interaction studies of Mycobacterium tuberculosis during host infection



Pavan Gollapalli1*, Manjunatha Hanumanthappa1, Sharath Pattar1

1 Department of Biotechnology and Bioinformatics, Kuvempu University, Shankaraghatta, Shivamogga, Karnataka, India
2 National Bureau of Agricultural Insect Resources (NBAIR), Bangalore, India

* Corresponding Author

ABSTRACT

The protein-protein Interaction study was used to understand the complex mechanism of the Mycobacterium bacterium in host. The literature scanning has been performed to investigate proteins involved in causing virulence, growth (up regulated genes) and survival of the pathogen in the diverse host environment by using web databases. The network of protein interactions was constructed by searching the primary interactions of seed proteins. The constructed network was analyzed by mathematical models to extract the biological significance of selected proteins. The results provide hub proteins such as Pyk and rpoB along with neighboring important nodes in the network. These proteins were used to understand their role in specific pathways to study biological significance to identify them as Bottleneck proteins. The hubs can be further analyzed biologically to identify them as targets to knockdown particular mechanism that stops survival and growth of the bacilli in the human host.

 


Copyright © 2015 | AIZEON publishers | All rights reserved

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Citation: Pavan Gollapalli et al. (2015). In Silico protein-protein interaction studies of Mycobacterium tuberculosis during host infection. Int J Comput Bioinfo In Silico Model 4(3): 673-682

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