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Copyright © 2015 | AIZEON publishers | All rights reserved

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International Journal of Computational Bioinformatics and In Silico Modeling
2015: Volume-4 Issue-3
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 4(3) 2015: 659-666

Study of Interaction between Wild type and Mutant HIV-1 protease and Cyclic Urea Inhibitor Using In Silico Techniques



Saba Sheikh*, Tanvee Pardeshi, Shama Mujawar, Krishna Deshmukh, Nidhi Sood, Preety Sharma and Sameer Chaudhary

RASA Life Science Informatics, 301, Dhanashree Apartments, opposite Chitaranjan Vatika, Model colony, Shivaji Nagar Pune- MH 411016, INDIA. Phn: +912065600408

* Corresponding Author

ABSTRACT

HIV-1 protease is a 99 amino acid aspartyl protease which is responsible for the cleavage of the viral polyprotein into functional constituent proteins. Inhibition of HIV protease causes the release of immature and noninfectious particles. Cyclic Urea inhibitors are seven member ring structure of cyclic urea compound. These inhibitors strongly bind with HIV-1 protease and are responsible for the formation of mature HIV which stops the cleavage of long viral protein into small peptide segment. Computational approaches were used to dock ligand (cyclic urea inhibitors) with HIV-1 proteases (mutated and wild type) to study their binding interaction and other properties. An ADME Toxicity property shows the best possible choice of drug against HIV-1 protease. Our in silico results approach that the mutated protein can bind with some of the Cyclic Urea inhibitors derivatives, which can block the functioning of HIV-1 protease, can be taken into consideration for further studies.

 


Copyright © 2015 | AIZEON publishers | All rights reserved

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Citation: Saba Sheikh et al. (2015). Study of Interaction between Wild type and Mutant HIV-1 protease and Cyclic Urea Inhibitor Using In Silico Techniques. Int J Comput Bioinfo In Silico Model 4(3): 659-666

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