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Copyright © 2015 | AIZEON publishers | All rights reserved

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International Journal of Computational Bioinformatics and In Silico Modeling
2015: Volume-4 Issue-1
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 4(1) 2015: 578-584

In silico designing of therapeutic small interfering RNA (si RNA) for lynch syndrome silencing



Neha Singh1, ShyamSundar1, Dhananjaya1*, Mallesha2 and Ravikumar1

1 Research and Development Center, Robust Materials Technology Pvt. Ltd., Bengaluru, Karnataka
2 Research and Development Center, Robust Herbal Pvt. Ltd., Bengaluru, Karnataka

* Corresponding Author

ABSTRACT

Lynch Syndrome is a hereditary disorder caused by a mutation in a Mismatch Repair gene (MLH1, MSH2, MSH6, PMS2, and EPCAM-TACSTD1) which affected persons have a higher than normal chance of  increasing Colorectal Cancer, Endometrial Cancer which also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC). The mutation of a single gene dramatically increases as well as the chances of contracting cancer increases deletion in mismatch repair gene responsible for lynch syndrome. All genes work in solving mistakes which causes by DNA which is copied in preparation for cell division. The damage in genes prohibit repair of DNA mistakes and as cells segregate, defects stack and uncontrollable cell growth may result in cancer. A total of 60 siRNA were identified in silico, in which 6 most potentially siRNA were selected that noted the therapeutic and have high potential of targeted gene silencing in lynch syndrome. These therapeutic siRNA will be useful to knockdown the translation process in targeted gene causing Lynch syndrome. The siRNA have great potential to control the cancerous disease.

 


Copyright © 2015 | AIZEON publishers | All rights reserved

 

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Citation: Neha Singh et al. (2015). In silico designing of therapeutic small interfering RNA (si RNA) for lynch syndrome silencing. Int J Comput Bioinfo In Silico Model 4(1): 578-584

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