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International Journal of Computational Bioinformatics and In Silico Modeling
2014: Volume-3 Issue-6
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 3(6) 2014: 549-552

Computational Analysis of Argonaute Protein Interactions Using Mirror Tree Approach



Pallavi Singh*

Department of Biotechnology, IILM ACADEMY OF HIGHER LEARNING, Greater Noida-201308, India

* Corresponding Author

ABSTRACT

Argonaute proteins have been well characterized for their key role in RNA mediated gene silencing pathways. Association of Argonaute proteins with siRNA to form RISC (RNA induced silencing complex) to catalyze post transcriptional gene silencing by degrading and slicing messenger RNA is established as a significant role of Argonaute protein family. Current work proposes the interaction of Argonaute proteins with DEXD c and Helicase C domain containing protein, RNA helicase LGP2 based on similarity in the phylogenetic distance matrices of the two proteins which is inferred from results obtained by implementation of mirror tree approach. Further verification of this potential interaction has been done by applying different online tools for the prediction of subcellular localization of Argonaute proteins and RNA helicase LGP2. Subcellular localization has shown that like Argonaute proteins, RNA helicase LGP2 is also localized to cytoplasm.

 


Copyright © 2014 | AIZEON publishers | All rights reserved

 

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Citation: Pallavi Singh (2014). Computational Analysis of Argonaute Protein Interactions Using Mirror Tree Approach. Int J Comput Bioinfo In Silico Model 3(6): 549-552

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