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International Journal of Computational Bioinformatics and In Silico Modeling
2014: Volume-3 Issue-6
ISSN: 2320-0634

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International Journal of Computational Bioinformatics and In Silico Modeling 3(6) 2014: 543-548

A comprehensive Hemophilia Interaction Network Model



Aman Chandra Kaushik, Anshul Raghuvanshi and Shakti Sahi*

School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India

* Corresponding Author

ABSTRACT

Haemophilia is a bleeding disorder in which the clotting mechanism does notwork properly and it slows down the blood clotting. Persons with this condition experience prolonged bleeding followed by an injury. There are basically two genes which are mainly responsible for this disease (F8 and F9).This paper focuses on finding out novel interaction between genes as well as proteins involved in process and constructing the pathway using system biology (Cell Designer http://celldesigner.org/). According to the concentration of the molecules, the reaction protocols were defined for simulation type using mass action kinetics equations V= k* π *Si or irreversible Michaelis-Menten equations V= Vm*S/Km+S. Then the parameter like time span, error tolerance and solver were set and finally the haemophilia pathway was executed for simulation. The following data was generated: simulation graph, Signal Injection: Pulse response graph and Reaction Rate(s) Vs Species graph of Haemophilia pathway. This pathway is useful in identifying novel genes as well as proteins which interact with F8 genes with respect to time.

 


Copyright © 2014 | AIZEON publishers | All rights reserved

 

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Citation: Aman Chandra Kaushik et al. (2014). A comprehensive Hemophilia Interaction Network Model. Int J Comput Bioinfo In Silico Model 3(6): 543-548

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