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International Journal of Computational Bioinformatics and In Silico Modeling
2014: Volume-3 Issue-5
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 3(5) 2014: 473-478

Homology modeling and structural analysis of human N-acetyl-alpha-neuraminidase 3 (NEU3)



Hideaki Yamaguchi*

Department of Pharmacy, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku, Nagoya 468-8503, Japan.

* Corresponding Author

ABSTRACT

Homology modeling and structural analysis of human N-acetyl-alpha-neuraminidase 3 (NEU3) were performed with a software package the Molecular Operating Environment. A human NEU2 (PDB code: 1SNT) was selected as a template for the 3D structure modeling of NEU3. The modeled NEU3 showed significant 2D and 3D similarities to NEU2. The contact energy profiles of the NEU3 model were in good agreement with those of the NEU2 structure. Ramachandran plots revealed that only 2.5% of the amino acid residues were in the disfavored region for NEU3. These results indicate that the NEU3 model was successfully modeled and analyzed. To the best of my knowledge, this is the first report of NEU3 model with detailed analyses, and the data verify that the model can be utilized for application to target NEU3 for the development of anticancer drugs.

 


Copyright © 2014 | AIZEON publishers | All rights reserved

 

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Citation: Hideaki Yamaguchi. (2014). Homology modeling and structural analysis of human N-acetyl-alpha-neuraminidase 3 (NEU3). Int J Comput Bioinfo In Silico Model 3(5): 473-478

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