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International Journal of Computational Bioinformatics and In Silico Modeling
2014: Volume-3 Issue-3
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 3(3) 2014: 381-387

Homology Modeling, Molecular Dynamic Simulation and Phylogenetic Analysis of Human Transient Receptor Potential Melastatin 1 (TRPM1)



A Wadood1*, Ashfaq Ur Rehman1, Sulaiman Shams1, Momin Khan2, Taj Ur Rahman2, Syed Babar Jamal1, Asifullah Khan1, Ayaz Ahmad3 and Farman Ali4

1 Computational Medicinal Chemistry Laboratory, Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan-23200, Pakistan
2 Department of Chemistry, Abdul Wali Khan University Mardan, Mardan-23200, Pakistan
3 Department of Biotechnology, Abdul Wali Khan University Mardan, Mardan-23200, Pakistan
4 Department of Zoology, Abdul Wali Khan University Mardan, Pakistan

* Corresponding Author

ABSTRACT

TRPM1 (Transient receptor potential melastatin 1) was identified in 1998 as a protein down-regulated in highly metastatic melanoma cells. In Melanocytes, TRPM1 expression is necessary for the function of endogenous nonselective cation channels with constitutive activity, while experimentally down-regulating TRPM1 expression diminished these currents. The structural mechanism of TRPM1 is still unknown, so, we modeled the three dimensional structure to predict the structural mechanism of human TRPM1. MOE was utilized to generate three dimensional structure of the human TRPM1 candidate gene. The quality of the constructed model was checked by Rampage and ERRAT. Molecular-dynamics simulations were carried out to characterize the dynamic behavior of the protein. Our results showed an open motion of the protein in water solvent. The generated model will help in understanding the mechanism of TRPM1 protein and will provide an incentive for new studies.


Copyright © 2014 | AIZEON publishers | All rights reserved

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Citation: A Wadood et. al. (2014). Homology Modeling, Molecular Dynamic Simulation and Phylogenetic Analysis of Human Transient Receptor Potential Melastatin 1 (TRPM1). Int J Comput Bioinfo In Silico Model 3(3): 381-387

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