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International Journal of Computational Bioinformatics and In Silico Modeling
2014: Volume-3 Issue-3
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 3(3) 2014: 369-373

Analysis of Oxygen Affinity in Aquatic Amphibian - Homology Modeling of the Major Hemoglobin Component HbA from Ambystoma mexicanum



Abid Ali1, Tayyab Rehman2, Hamid Ur Rehman1 and Roshan Ali2*

1 Department of Zoology, Islamia College University, Peshawar 25120, Pakistan
2 Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan

* Corresponding Author

ABSTRACT

Ambystoma mexicanum an obligate paedomorphic species has large number of substitution in the interaction in Alpha and Beta chain residues of its hemoglobin that enable it to survive in hypoxic and lower oxygen pressure condition. To understand the mechanism of respiration in A. mexicanum we need to understand the three dimensional structure of its hemoglobin. In this study, we have built a three dimensional homology model of hemoglobin A (HbA) from A. mexicanum using bovine HbA as template. MODELLER was used to create three dimensional patterns and was evaluated with ProSA and PROCHECK. This study is about the analysis of effects of inter-subunit contacts on oxygen affinity of the hemoglobin. The effect of the following pairs of inter-subunit contacts on the oxygen affinity of the hemoglobin have been studied i.e. α99 and β101, α34 and β125, α38 and β99 and β97, α119and β55, α35 and β128, and α103 and β112. It has been predicted from the loss of interactions between these pairs of residues that A. mexicanum HbA might be able to tolerate hypoxic conditions and have greater oxygen affinity.


Copyright © 2014 | AIZEON publishers | All rights reserved

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Citation: Abid Ali et. al. (2014). Analysis of Oxygen Affinity in Aquatic Amphibian - Homology Modeling of the Major Hemoglobin Component HbA from Ambystoma mexicanum. Int J Comput Bioinfo In Silico Model 3(3): 369-373

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