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International Journal of Computational Bioinformatics and In Silico Modeling
2013: Volume-2 Issue-3
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 2(3) 2013: 128-131

Prediction of possible interaction of SoxK with SoxXA complex in Allochromatium vinosum through Protein-protein docking: An in silico approach


Sujay Ray* and Angshuman Bagchi

Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia, India.

* Corresponding Author

ABSTRACT

Three periplasmic Sox proteins encoded by the soxBXAK and soxYZ genes are mainly responsible for thiosulfate oxidation in Allochromatium vinosum. Thiosulphate (S2O32–) fulfils an important role in the natural sulphur cycle. It is a stable and environmentally abundant sulphur compound of intermediate oxidation state. Thiosulphate-oxidizing sox enzyme can be classified as two types, type one group forms sulphur globules as intermediate for ex Allochromatium vinosum and another which does not form sulphur globules as intermediate for ex example Paracoccus pantotrophus. It is well documented that thiosulphate oxidation in Allochromatium vinosum is mainly dependent on the presence of three periplasmic Sox proteins encoded by the soxB, soxXAK, and soxYZ genes. So the interactions between SoxXA complexes with soxK are very crucial to understand thiosulphate oxidation in Allochromatium vinosum. In the present work, homology modeling and ab-initio structure prediction have been used to build the three dimensional structures of SoxA, SoxX and SoxK. With the help of protein-protein docking complex structure of SoxAX is formed, The Cluspro 2.0 protein-protein docking and P.I.C server have been used to predict possible interaction between soxAX and soxK protein. The interactions between the SoxAX complex, and SoxK proteins are mediated mainly through hydrogen bonding, hydrophobic interaction, electrostatic interaction.

Copyright © 2013 | AIZEON publishers | All rights reserved

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Citation: Sujay Ray and Angshuman Bagchi. (2013). Prediction of possible interaction of SoxK with SoxXA complex in Allochromatium vinosum through Protein-protein docking: An in silico approach. Int J Comput Bioinfo In Silico Model 2(3): 128-131

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