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International Journal of Computational Bioinformatics and In Silico Modeling
2013: Volume-2 Issue-3
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 2(3) 2013: 115-122

Regulation of YAP in organ growth and Tumorigenesis: A comprehensive review


Pooja Purohit *, Suresh Jatawa and Archana Tiwari

School Of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, State Technological University of Bhopal, Airport Bypass Road, Bhopal, Madhya Pradesh-462033, India .

* Corresponding Author

ABSTRACT

YAP (Yes kinase-associated protein) is a transcriptional coactivator which plays key role in Hippo Signaling pathway. The Hippo pathway controls cell growth, proliferation and apoptosis by regulation of target genes mediated by core pathway proteins. YAP/Yki mediates gene expression by interacting with TEAD family transcription factors. However, YAP-TEAD interaction is also required for oncogenic transformation of cells. Three-dimensional crystal structure of YAP-TEAD complex has revealed extensive molecular details with highly conserved interfaces. The amino terminal domain of YAP in complex with the carboxy terminal domain of TEAD transcription factor provides vital information of molecular complexity. Here, we will review the basic Hippo signalling pathway and role of YAP as an oncogene. We will also discuss about the crystal structure of YAP in complex with TEAD, various molecular interactions between YAP-TEAD, and WW domain of YAP with PPxY motif peptides. Lastly, we will also provide a brief discussion on the implications of in silico analysis on inhibition of YAP-TEAD complex and development of novel anticancer therapeutics. Future directions for the research are outlined.

Copyright © 2013 | AIZEON publishers | All rights reserved

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Citation: Pooja Purohit et al. (2013). Regulation of YAP in organ growth and Tumorigenesis: A comprehensive review. Int J Comput Bioinfo In Silico Model 2(3): 115-122

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