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International Journal of Computational Bioinformatics and In Silico Modeling
2013: Volume-2 Issue-3
ISSN: 2320-0634

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ABSTRACT   REFERENCES  
International Journal of Computational Bioinformatics and In Silico Modeling 2(3) 2013: 110-114

Insights from the analysis of phosphorylation sites in the CK2 alpha catalytic subunit


Priyanka Dhar1*, Abhijit Datta2 and Ravi B. Srivastava1

1Defence Institute of High Altitude Research, Defence Research and Development Organisation, C/o 56 APO, Pin 901205, India.
2DBT Centre for Bioinformatics, Presidency University, Kolkata 700073, India.

* Corresponding Author

ABSTRACT

Protein kinase CK2 is a critical regulator of several cellular and molecular signaling pathways. CK2 is unanimously distributed in eukaryotes and subsists in tetrameric complexes comprising two catalytic alpha and two regulatory beta subunits. Several reports have confirmed that protein kinase CK2 has great significance in diverse biological courses, particularly in cellular growth and proliferation in normal and disease conditions. However, in silico analysis of phosphorylation sites in the catalytic alpha subunit of CK2 remain to be elucidated. We describe the distribution of predicted (neural network predictions for serine (S), threonine (T) and tyrosine(Y)) STY phosphorylation sites in 15 multicellular and 2 unicellular organisms. We also showed the clustering of CK2 alpha subunit in these organisms using a phylogram. This data showed the prevalence of CK2 alpha subunits with potential STY phophorylation sites in several eukaryotic unicellular and mulicellular organisms that could be significant in the context of enigmatic protein kinase activities of CK2, enzyme-substrate interactions, further ligand-binding studies and new therapeutic interventions.

Copyright © 2013 | AIZEON publishers | All rights reserved

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Citation: Priyanka Dhar et al. (2013). Insights from the analysis of phosphorylation sites in the CK2 alpha catalytic subunit. Int J Comput Bioinfo In Silico Model 2(3): 110-114

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