International Journal of Computational Bioinformatics and In Silico Modeling
ABSTRACT: Phosphatidylinositol 3-kinase is a very promising anti cancer drug target which is being actively investigated for treatment of various cancers such as RCC, prostrate, NSCLC and solid tumors. In this article, we have made an attempt to study the role of PI3K pathway inhibitors in the treatment of lung cancer through Insilco Molecular Docking studies. It was indicated from our study that the docking protocol could reliably predict how PI3K inhibitors act in NSCLC. The docking study carried out with 1M17 revealed that all six PI3K inhibitors have potential to work for NSCLC, but GDC-0941 (-7.03 kcal/mol) and GSK 2126458 (-8.30 kcal/mol) fits better than the rest.
KeyWords: Molecular Docking, NSCLC, PI3K, In Silico, AutoDock.
How to cite: Awantika et. al. Int J Comput Bioinfo In Silico Model. 2(1) 2013: 68-71
ABSTRACT: Abiotic stresses, such as salinity, drought, cold and adverse environmental conditions affect the growth of plants. Stresses are severe intimidation for cultivation and the usual status of the surroundings. The accessibility of Plant Transcription Factor Database and Rice Oligo Array Database create an achievable opportunity to recognize the least studied transcription factor/regulator genes in rice. On the basis of PCC (Pearson correlation co-efficient) cut-off value in the co-expression network analysis some least studied transcription factors/regulators were retrieved. Above retrieval has done by restricting the correlation co-efficient value for abiotic stress in Rice Oligo Array Database. The comparative analysis and evolutionary relationship of these transcription factors/regulators have been done using multiple sequence alignment and phylogenetic analysis, respectively. Depending on the co-expression networking in Rice Oligo Array Database, we have identified 39 genes having least information that belongs to 11 different transcription factors families and 7 transcription regulators in rice. Abundance of serine residue in protein sequences and transition substitution of Cytosine with Thymine in nucleotide sequences for all 39 transcription factors/regulators genes were noticed. Therefore, presence of serine might activate these transcription factors during drought and metal stress condition and have significant role in plant adaptation and stress response.
KeyWords: Transcription Factors, Gene co-expression, Networking, Abiotic stresses, Serine
How to cite: DM Pandey et al. Int J Comput Bioinfo In Silico Model. 2(1) 2013: 72-80
ABSTRACT: Among best-practice principles was the belief that the use of technology to enhance the learning experience of adults was of critical importance. In 1998, this was not tremendously surprising. E-mail and the Internet were already fairly well established in offices as well as in many homes. Students used computer databases to organize and access information. However, we were a long way from where we are now. Then, online learning was a fledgling offering by just a few institutions and providers. Most homes had only dial-up access to the Internet, rather than today?s high-speed broadband. And college applications were still mostly paper-based rather than online forms. The subsequent speed with which online learning went from a niche offering to one that is a common option within academia has been striking. The National Center for Education Statistics (NCES) reports that in 1999?2000, only 8 percent of undergraduates took at least one distance-education (including online) course during the survey year, but by 2007?2008, more than 20 percent of undergraduates had done so. This more than doubling of participation in distance/online learning in eight years is even more remarkable given that in 1995-1996, NCES surveys did not even include the question about distance education. Since that APQC the American Productivity & Quality Center (APQC) benchmarking study, we have seen the kind of technological progress that many of us could not have imagined, including technology?s applications in postsecondary learning and degree completion. This paper is highlighting how these advances have changed the college experience and its outcomes; this paper focuses on some of the changes that occur for the nontraditional student. One of these changes is the use of online learning and degree programs specifically tied to career pathways, another is the use of online portals that recognize and document college-level learning from various sources, and a third is the development of online tools that help students understand the connections between and among current skills, degree programs, and possible occupations. These innovations are helping to highlight learning outcomes rather than inputs, and they are helping nontraditional learners access degree programs that employers value and that accommodate the schedule of the working world.
KeyWords: postsecondary education, learning programs, education, learning assessments
How to cite: Nya Joe Jacob. Int J Comput Bioinfo In Silico Model. 2(1) 2013: 81-86